| BRIEF REPORT |
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| Year : 2009 | Volume
: 15
| Issue : 1 | Page : 28-31 |
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Chromosomal abnormalities associated with mental retardation in female subjects
Samikshan Dutta, Jyoti Shaw, Swagata Sinha, Kanchan Mukhopadhyay
Manovikas Biomedical Research and Diagnostic Centre, 482, Madudah, Plot I-24, Sec.-J, E.M. Bypass, Kolkata - 700 107, India
Correspondence Address:
Kanchan Mukhopadhyay
Manovikas Biomedical Research and Diagnostic Centre, 482, Madudah, Plot I-24, Sec.-J, E.M. Bypass, Kolkata - 700 107
India
DOI: 10.4103/0971-6866.50867 PMID: 20407647
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Chromosomal abnormalities are thought to be the most common cause of mental retardation (MR). However, apart from a few selected types with typical aneuploidy, like Downs syndrome, Klinefelter syndrome, Turner syndrome, etc., the frequency of detectable chromosomal abnormalities in association with idiopathic MR is very low. In this study, we have investigated chromosomal abnormalities in female MR subjects (n = 150) by high-resolution GTG banding. Of them, 30 cases were diagnosed as Downs syndrome. Among the remaining (n = 120), chromosomal abnormalities/marked polymorphisms were detectable in only three MR cases (0.025). |
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