Indian Journal of Human Genetics
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ORIGINAL ARTICLE
Year : 2008  |  Volume : 14  |  Issue : 3  |  Page : 99-102

Allelic variants of DYX1C1 are not associated with dyslexia in India


1 Department of Studies in Zoology, Human Genetics Laboratory, University of Mysore, Manasagangothri, Mysore-570 006, India
2 Anthropological Survey of India, Southern Regional Centre, Manav Bhavan,Bogadi II Stage, Mysore-570 006, India

Correspondence Address:
Nallur Basappa Ramachandra
Department of Studies in Zoology, Human Genetics Laboratory, University of Mysore, Manasagangothri, Mysore-570 006
India
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DOI: 10.4103/0971-6866.45002

PMID: 20300304

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Dyslexia is a hereditary neurological disorder that manifests as an unexpected difficulty in learning to read despite adequate intelligence, education, and normal senses. The prevalence of dyslexia ranges from 3 to 15% of the school aged children. Many genetic studies indicated that loci on 6p21.3, 15q15-21, and 18p11.2 have been identified as promising candidate gene regions for dyslexia. Recently, it has been suggested that allelic variants of gene, DYX1C1 influence dyslexia. In the present study, exon 2 and 10 of DYX1C1 has been analyzed to verify whether these single nucleotide polymorphisms (SNPs) influence dyslexia, in our population. Our study identified 4 SNPs however, none of these SNPS were found to be significantly associated with dyslexia suggesting DYX1C1 allelic variants are not associated with dyslexia.


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