Indian Journal of Human Genetics
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Year : 1997  |  Volume : 3  |  Issue : 1  |  Page : 25-32

Significance Of Elevated Sister Chromatid Exchange Frequency In Gastrointestinal Cancer


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Vasudha Sambyal


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Spontaneous sister chromatid exchange (SCE) were studied in leukocytes of 64 patients 32 males and 32 females) with malignancy of various parts of Gastrointestinal (GI) tract prior to beginning any anticancer treatment. In five female patients, SCE were analyzed again 4 years post-treatment. Data from 50 (25 males and 25 females) age matched normal healthy individuals formed the controls. The patients had significantly higher SCE frequency than controls. The SCE/Cell in male patients was 14.49 + 4.00 and in male controls was 9.52 + 4.14. The SCE/Cell in female patients was 13.41 + 3.97 and in female controls was 8.27 + 2.12 patients with advanced stage tumors had significantly higher SCE/Cell value than early stage tumors. When male and female patients were taken together, patients with well differentiated tumors had SCE/Cell value 9.1+ 1.94, with moderately differentiated tumors had 12.05+1.92 and poorly differentiated tumours had 16.66 + 2.95. In five female patients, the SCE frequency 4 years post-treatment was significantly decreased, i.e., 6.61 + 1.12 as compared to their preoperative SCE value i.e., 9.98 + 1.07


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